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CJC 1295

GHRH Analog

CJC 1295 has shown promising results as a Growth Hormone Releasing (GHRH) analog. Not only has CJC 1295 shown potential to increase growth hormone and IGF-1 secretion and effects, but it has been able to do so in very large amounts. CJC 1295 stimulates Growth Hormone secretion and will keep a steady increase of HGH and IGF-1 with no increase in prolactin, leading to fat loss, and increased protein synthesis thereby promoting growth.

CJC 1295 is a tetra-substituted 30 amino acid peptide hormone, primarily functioning as a Growth Hormone Releasing Hormone (GHRH) analog.

Advantages of CJC 1295 over regular GHRH or rHGH:

  • Ability to bioconjugate with serum albumin, thus increasing its half-life and therapeutic window.

  • CJC 1295 can be compounded in two forms (DAC and non-DAC). Drug Affinity Complex (DAC) prevents enzymatic degradation which in turn increases the half-life. Consequently, CJC 1295-DAC can be dosed as a single weekly injection. Administration of CJC 1295-DAC provides a GHRH-like stimulation around the clock

  • CJC 1295-non-DAC is typically dosed for 5 days out of 7. Therefore, using CJC 1295-non-DAC daily (between 6:00-8:00pm) provides a more effective GH spike at 1:00 am, unlike dosing weekly with CJC 1295-DAC

Various experiments have been conducted to test the effectiveness of CJC 1295-DAC in vivo and the Journal of Clinical Endocrinology & Metabolism has reported dose-dependent increases in mean plasma GH concentrations by 2-10-fold for more than 6 days and increased IGF-1 concentrations 1.5-3-fold for 9-11 days after a single injection. Mean half-life was shown to be 5.8-8.1 days, also after multiple doses mean IGF-1 levels remained above baseline for up to 28 days. No serious adverse reactions were reported in any group.

Another benefit of CJC 1295 is its ability to promote slow wave sleep. Slow wave sleep is also known as deep sleep and is the portion of sleep responsible for the highest level of muscle growth and memory retention. Slow wave sleep, SWS, decreases significantly in older adults and with people who tend to exercise late in the evening. Clinical studies have shown that a once-daily administration of CJC 1295 normalizes GHRH response and can induce significantly deeper sleep.

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